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Why Mathematics? | Fractional Factorial Designs: Alias Structures, Resolution and Efficient Screening

Why is mathematics important when a full experiment has too many factor combinations to run? Fractional factorial designs choose a structured subset of runs. Generators, defining relations and resolution reveal exactly which effects are aliased, turning a small screening experiment into an honest map of what can and cannot be learned.

Did You Know? A four-factor two-level full factorial needs 16 runs, but a half-fraction needs 8. The saving is real because some effects become mathematically indistinguishable, not because the missing information somehow disappears.

Full chapter index

Chapters 1–7 · Understand the question
  1. The screening problem
  2. Full factorial benchmark
  3. Take a half-fraction
  4. Choose a generator
  5. Defining relation
  6. Derive aliases
  7. Resolution IV meaning
Chapters 8–14 · Reproduce the example
  1. Worked alias set
  2. Resolution III
  3. Resolution V
  4. NIST resolution guidance
  5. Sparsity of effects
  6. Effect hierarchy
  7. Effect heredity
Chapters 15–21 · Check assumptions
  1. Randomise run order
  2. Centre points
  3. Replication
  4. Foldover
  5. Sequential experimentation
  6. Minimum aberration
  7. Blocking
Chapters 22–28 · Explore applications
  1. Missing runs
  2. Education example
  3. AI example
  4. Diagnostics
  5. Validation plan
  6. Limits
  7. Communication
Chapters 29–42 · Study and verify
  1. Final decision
  2. A spreadsheet workflow
  3. A coding workflow
  4. Applications and careers
  5. A student investigation
  6. Common misconceptions
  7. Connection to recent mathematics articles
  8. Guidance for students and parents
  9. Practice questions
  10. Frequently asked questions
  11. A reporting checklist
  12. The design matrix is the evidence contract
  13. A final fraction audit
  14. Useful next reading

CHAPTER 1 OF 42 · Understand the question

1. The screening problem

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Engineers, teachers and AI teams may have many possible factors but limited time. A screening design identifies a small set worth deeper study before optimisation.

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CHAPTER 2 OF 42 · Understand the question

2. Full factorial benchmark

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Four factors at two levels create 2^4=16 combinations. The full design estimates all main effects and interactions when replication and noise permit.

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CHAPTER 3 OF 42 · Understand the question

3. Take a half-fraction

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A 2^(4−1) half-fraction uses eight combinations. It keeps orthogonal structure while deliberately confounding selected effects.

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CHAPTER 4 OF 42 · Understand the question

4. Choose a generator

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Let D=ABC using coded levels -1 and +1. For every chosen run, the D column is the product of A, B and C.

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CHAPTER 5 OF 42 · Understand the question

5. Defining relation

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Multiplying both sides by D gives I=ABCD. This shortest word has length four, so the design is resolution IV.

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CHAPTER 6 OF 42 · Understand the question

6. Derive aliases

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Multiply I=ABCD by an effect. A=BCD, while AB=CD. The algebra lists every effect that produces the same design column.

Full designFractionGeneratorRuns
2^42^(4-1)D=ABC8
Illustrative half-fraction.

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CHAPTER 7 OF 42 · Understand the question

7. Resolution IV meaning

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Main effects are not aliased with two-factor interactions, but two-factor interactions are paired with other two-factor interactions.

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CHAPTER 8 OF 42 · Reproduce the example

8. Worked alias set

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The illustrative design has AB=CD, AC=BD and AD=BC. An observed AB signal could be CD or a mixture; the data alone cannot decide.

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CHAPTER 9 OF 42 · Reproduce the example

9. Resolution III

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Main effects can be aliased with two-factor interactions. This may be acceptable for rough screening only when interaction sparsity is plausible.

EffectAliased with
ABCD
ABCD
ACBD
ADBC
Resolution IV alias examples.

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CHAPTER 10 OF 42 · Reproduce the example

10. Resolution V

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Main effects and two-factor interactions are clear of each other, though two-factor interactions can alias with three-factor interactions. More runs are usually required.

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CHAPTER 11 OF 42 · Reproduce the example

11. NIST resolution guidance

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NIST defines resolution from the shortest word and summarises the aliasing patterns of resolution III, IV and V designs. Read the NIST handbook.

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CHAPTER 12 OF 42 · Reproduce the example

12. Sparsity of effects

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Screening assumes only a few effects are active. This is a scientific working assumption, not a theorem, and should guide confirmation.

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CHAPTER 13 OF 42 · Reproduce the example

13. Effect hierarchy

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Lower-order effects are often more plausible than high-order interactions. A strong higher-order effect can still break that expectation.

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CHAPTER 14 OF 42 · Reproduce the example

14. Effect heredity

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An interaction is often more plausible when at least one parent main effect is active. Heredity helps interpretation but cannot resolve aliases from data alone.

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CHAPTER 15 OF 42 · Check assumptions

15. Randomise run order

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The fraction chooses combinations; randomisation protects them from time, machine warm-up or learner fatigue.

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CHAPTER 16 OF 42 · Check assumptions

16. Centre points

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Adding centre runs for quantitative factors can detect overall curvature, though a two-level fraction cannot identify separate quadratic terms.

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CHAPTER 17 OF 42 · Check assumptions

17. Replication

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Replicating runs estimates pure error and improves precision. Repeating the same biased order does not protect against drift.

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CHAPTER 18 OF 42 · Check assumptions

18. Foldover

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A foldover reverses signs for selected factors and can break important aliases. Choose the follow-up based on the specific ambiguous effects.

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CHAPTER 19 OF 42 · Check assumptions

19. Sequential experimentation

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Screen first, add confirmation runs, then move to response-surface optimisation. One small fraction should not carry every conclusion.

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CHAPTER 20 OF 42 · Check assumptions

20. Minimum aberration

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Designs with the same resolution can have different counts of short defining words. Minimum-aberration choices reduce severe aliasing.

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CHAPTER 21 OF 42 · Check assumptions

21. Blocking

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If runs span days or batches, block the design using high-order columns. The block effect then aliases with chosen interactions and must be documented.

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CHAPTER 22 OF 42 · Explore applications

22. Missing runs

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A failed run can destroy orthogonality and complicate the alias structure. Re-run when possible or analyse the actual rank and variance inflation.

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CHAPTER 23 OF 42 · Explore applications

23. Education example

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A learning experiment screens feedback timing, example type, retrieval schedule and group size. Eight combinations may reveal promising factors, but aliased interactions need follow-up.

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CHAPTER 24 OF 42 · Explore applications

24. AI example

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Training experiments can screen learning rate, augmentation, batch size and regularisation. Random seeds and compute batches act as replication or blocks.

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CHAPTER 25 OF 42 · Explore applications

25. Diagnostics

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Inspect design-matrix correlations, alias chains, residuals, run order, effect plots and leverage. Never report an effect name without its alias set.

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CHAPTER 26 OF 42 · Explore applications

26. Validation plan

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Build the eight-run matrix, verify D=ABC, multiply columns to confirm aliases and add a foldover to separate AB from CD.

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CHAPTER 27 OF 42 · Explore applications

27. Limits

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Fractionation cannot estimate every effect, protect against changing processes or validate an untested region. Efficiency is purchased with assumptions.

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CHAPTER 28 OF 42 · Explore applications

28. Communication

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Report generators, defining relation, resolution, complete relevant alias structure, randomisation, blocks, centre points and confirmation runs.

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CHAPTER 29 OF 42 · Study and verify

29. Final decision

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Use the highest feasible resolution that protects the effects you care about. Let scientific priorities determine which aliases are acceptable.

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CHAPTER 30 OF 42 · Study and verify

30. A spreadsheet workflow

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Create columns for run, coded factors, generator checks, block, order, response and every estimable contrast.

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CHAPTER 31 OF 42 · Study and verify

31. A coding workflow

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Construct the design matrix, verify column products and rank, print alias chains and unit-test the planned randomisation.

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CHAPTER 32 OF 42 · Study and verify

32. Applications and careers

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Process engineers, agronomists, education researchers and AI experimenters use fractions to screen many controllable choices efficiently.

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CHAPTER 33 OF 42 · Study and verify

33. A student investigation

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Create a 2^(4−1) fraction with D=ABC, simulate an AB effect and show why it is indistinguishable from CD before foldover.

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CHAPTER 34 OF 42 · Study and verify

34. Common misconceptions

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A small p-value does not identify one member of an alias chain, resolution is not data quality, and sparsity is an assumption rather than a guarantee.

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CHAPTER 35 OF 42 · Study and verify

35. Connection to recent mathematics articles

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The factorial-experiment guide gives the full-design foundation. The multiple-testing guide explains screening claims.

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CHAPTER 36 OF 42 · Study and verify

36. Guidance for students and parents

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Students should multiply coded columns by hand for one alias. Parents can ask whether an education experiment confirmed signals in new combinations.

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CHAPTER 37 OF 42 · Study and verify

37. Practice questions

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  • Count full and fractional runs.
  • Derive I=ABCD.
  • Find the AB alias.
  • Add a foldover.
  • Inspect a missing run.

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CHAPTER 38 OF 42 · Study and verify

38. Frequently asked questions

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### What is aliasing? Two or more effects share the same design column.

### Is resolution IV always enough? No.

### Why centre points? To detect overall curvature.

### Must screening be followed up? Strongly recommended.

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CHAPTER 39 OF 42 · Study and verify

39. A reporting checklist

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Report factors and levels, fraction, generator, defining relation, resolution, alias sets, blocks, randomisation, replication, missing runs, model and confirmation plan.

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CHAPTER 40 OF 42 · Study and verify

40. The design matrix is the evidence contract

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Every estimable claim is encoded in its columns before a response is measured.

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CHAPTER 41 OF 42 · Study and verify

41. A final fraction audit

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Confirm the intended effects are not fatally aliased, all runs match the generator and conclusions name unresolved alternatives.

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CHAPTER 42 OF 42 · Study and verify

42. Useful next reading

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Continue through the Mathematics Learning Hub. Recalculate the central example, identify the assumptions and explain which claim the result can and cannot support.

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Extended practice laboratory

Practice case 1: List factors

Setup: Start from the article’s fractional factorial mechanism for case 1. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 2: Choose two levels

Setup: Start from the article’s fractional factorial mechanism for case 2. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 3: Count full runs

Setup: Start from the article’s fractional factorial mechanism for case 3. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 4: Choose fraction

Setup: Start from the article’s fractional factorial mechanism for case 4. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 5: Set generator

Setup: Start from the article’s fractional factorial mechanism for case 5. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 6: Write defining relation

Setup: Start from the article’s fractional factorial mechanism for case 6. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 7: Derive A alias

Setup: Start from the article’s fractional factorial mechanism for case 7. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 8: Derive AB alias

Setup: Start from the article’s fractional factorial mechanism for case 8. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 9: Identify resolution

Setup: Start from the article’s fractional factorial mechanism for case 9. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 10: Randomise runs

Setup: Start from the article’s fractional factorial mechanism for case 10. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 11: Replicate centre

Setup: Start from the article’s fractional factorial mechanism for case 11. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 12: Estimate main effects

Setup: Start from the article’s fractional factorial mechanism for case 12. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 13: Inspect interaction alias

Setup: Start from the article’s fractional factorial mechanism for case 13. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 14: Use foldover

Setup: Start from the article’s fractional factorial mechanism for case 14. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 15: Add confirmation runs

Setup: Start from the article’s fractional factorial mechanism for case 15. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 16: Check sparsity assumption

Setup: Start from the article’s fractional factorial mechanism for case 16. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 17: Check hierarchy

Setup: Start from the article’s fractional factorial mechanism for case 17. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 18: Add blocks

Setup: Start from the article’s fractional factorial mechanism for case 18. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 19: Check run order

Setup: Start from the article’s fractional factorial mechanism for case 19. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 20: Fit coded model

Setup: Start from the article’s fractional factorial mechanism for case 20. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 21: Plot effects

Setup: Start from the article’s fractional factorial mechanism for case 21. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 22: Simulate hidden interaction

Setup: Start from the article’s fractional factorial mechanism for case 22. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 23: Audit design matrix

Setup: Start from the article’s fractional factorial mechanism for case 23. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 24: Name limits

Setup: Start from the article’s fractional factorial mechanism for case 24. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.

Practice case 25: Write conclusion

Setup: Start from the article’s fractional factorial mechanism for case 25. Task: Change the named quantity, recompute the dependent result and compare with the original.

Check: Preserve the estimand and design, verify the statistical identity, state one diagnostic, record units and compare one defensible alternative with clear reasoning. Show the arithmetic, name the response and predictor units, and separate the numerical result from the claim it supports. Then vary one defensible assumption, calculate again and explain whether the conclusion changed because of the data, the fitted model or the validation purpose. Finish with one compact table or graph that could reveal a failure hidden by the summary.